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Genelux Corporation Announces Ground-Breaking Clinical Study Evaluating Oncolytic Vaccinia Virus in Canine Cancer Patients
May 31, 2012


Veterinary Oncologist Dr. Gregory K. Ogilvie to lead clinical study


SAN DIEGO, May 31,2012 -- Genelux Corporation, a privately-held clinical-stage biopharmaceutical company focused on development and commercialization of best–in-class vaccinia virus based oncolytic viral therapies and companion diagnostics for human cancer patients, today announced the start of  a ground-breaking clinical study involving the oncolytic Vaccinia virus V-VET1 in canine cancer patients with various measurable malignancies. Although oncolytic viruses are being more extensively evaluated in humans, this study is the first of its kind ever reported in dogs, and will evaluate the safety, dosing and efficacy  of V-VET1, a veterinary-use, intravenously-delivered  oncolytic Vaccinia virus.

 

 

 “V-VET1 is a specially-designed veterinary product candidate that has shown encouraging safety and efficacy results in preclinical studies against a number of cancers afflicting dogs, including Canine Soft Tissue Sarcoma,” said Dr. Aladar Szalay, Founder and CEO of Genelux Corporation.” It is based on Genelux Corporation’s proprietary product platform that potentially can deliver both therapeutic and diagnostic constructs directly to tumors without harming healthy tissues or cells. We are very pleased to be working with a world- renowned Veterinary Oncologist and Internal Medicine specialist like Dr. Gregory Ogilvie  to assess V-VET1 in dogs.“

 

“This is a tremendously exciting time in veterinary oncology as novel therapies like V-VET1 have the potential fundamentally to change the way veterinarians treat companion animals with advanced cancer,” says Dr. Gregory K. Ogilvie, DVM, study Principal Investigator and Director of the CVS Angel Care Cancer Center in Carlsbad, California. “This novel therapy has the potential selectively to kill tumors and metastases while sparing our beloved canine patients the many negative side effects of conventional therapies like chemo and radiation”.

 

Canine clinical studies also have potentially broader applicability. Dr. Ogilvie, who has spent many years in translational medicine adds, “Companion animal clinical study results often translate in important ways to pediatric clinical trials. The similarities in the way certain canine cancers like osteosarcoma, for example, develop and behave, are nearly identical to those in pediatric patients.  It is our hope that, in addition to helping our companion animals, this study can eventually serve also as the basis for additional important studies in pediatric cancer patients.” 

 

The open-label dose-escalation study will be conducted on site at California Veterinary Specialists (CVS) Angel Care Cancer Center, based in Carlsbad, California. For additional information, please visit www.cvsangelcare.com.

 

About V-VET1

 

V-VET1 is a genetically characterized, veterinary-grade replication-competent oncolytic vaccinia virus-based therapy derived from the LIVP vaccinia virus strain.  It is systemically administered to deliver a multi-pronged attack on cancer:  1) V-VET1 selectively enters and lyses (kills) cancer cells through replication and amplification within cancer cells, causing cells to rupture and viral progeny to infect neighboring cancer cells;  2) tumor vasculature is destroyed during this process, reducing significantly the blood supply that enables tumors to grow; and 3)) the oncolytic process stimulates innate and adaptive immune responses resulting in tumor rejection (similar to immune-mediated tissue-specific  destruction).  Future derivatives of V-VET 1 can potentially carry and over-express therapeutic, deep tissue imaging, or immuno-modulatory genes for production within the tumor.

 

About CVS Angel Care Cancer Center

 

The California Veterinary Specialists (CVS) Angel Care Cancer Center, based in Carlsbad, California is a comprehensive group within the CVS specialty/critical care hospitals that provides direct care for companion animal patients with cancer and their families. CVS offers the most innovative clinical research, diagnostics and treatments available to fight against cancer. The Angel Care Cancer Center specializes in Medical oncology, Radiation Oncology/Diagnostic Imaging, Surgical Oncology and Emergency and Critical Care, and offers some of the most experienced and highly trained board certified veterinary medical professionals and state of the art facilities in the world

 

About Genelux Corporation


Genelux Corporation was founded in 2001 with a mission to develop safe and effective diagnostic and therapeutic solutions for cancer and inflammatory diseases for which there are no effective treatments today. Genelux Corporation is headquartered in San Diego, California. For additional information, please visit www.genelux.com.

 

Genelux Forward Looking Statement


Statements made about Genelux Corporation, other than statements of historical fact, reflect Management’s current beliefs and assumptions founded on the data and information currently available to us. Statements of the company’s progress, results, timing of pre-clinical and clinical trials and projections for product pipelines are examples of forward-looking statements. By definition, such undertakings involve risks, uncertainties and assumptions, and are subject to a number of such factors that could cause actual results to differ substantially from statements made, including but not limited to: risks associated with the success of clinical trials, research and development programs, regulatory approval processes for clinical trials, competitive technologies and products, patents, inception and/or continuation of corporate and other strategic partnerships and the need for additional funding or financing. 




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